Background: The mean age was 48.44 years and the mean duration of diagnosis was 6.5 years. The most common side effects is the increased hair on the face (especially upper lip) and body that some patients get. USA.gov. 2) Effectiveness and safety of low-dose oral minoxidil in male androgenetic alopecia. 9) Minoxidil: mechanisms of action on hair growth. Together, these studies speak to a relatively good safety profile of oral minoxidil. Rod Sinclair from Australia set out to study the potential benefits of using oral minoxidil and oral spironolactone together. Referencias bibliográficas: SINCLAIR RD. hide. 0 comments. Hi there, I’m a 25 year old who just started on oral minoxidil 0.25mg and 25mg spironolactone. Oral minoxidil for hair loss At Salford Royal, patients are considered eligible for oral minoxidil treatment if their hair loss has not responded to topical minoxidil or if these products are not tolerated. Oral minoxidil is available as a 2.5-milligram (mg) and 10-mg white pill. Minoxidil and spironolactone are oral antihypertensives known to stimulate hair growth. Rossi A, Cantisani C, Melis L, Iorio A, Scali E, Calvieri S. Recent Pat Inflamm Allergy Drug Discov. 1 Coincidentally, physicians observed hair regrowth and generalized hypertrichosis in balding patients, which led to the development of a topical minoxidil formulation for treating androgenetic alopecia (AGA) first in male and then in female individuals. Dermatol Ther (Heidelb). Prescribing Habits for Androgenic Alopecia among Dermatologists in Spain in 2019-2020: A Cross-Sectional Study. Antiandrogen therapy with either spironolactone or cyproterone acetate is commonly used to treat FPHL, as is topical minoxidil.  |  This is an interesting study. NLM Results: To report on a case series of women with pattern hair loss (PHL) treated with once daily minoxidil 0.25 mg and spironolactone 25 mg. Methods: As alopecia is highly visible, a patient may note hair loss as the first symptom of a host of underlying or contributing medical and psychiatric conditions. 3 The use of topical minoxidil together with an oral antiandrogen might have an additive effect; however, combination therapy has not been previously reported. The ease of taking oral minoxidil vs topical minoxidil does make it a important option for further study. F1000Res.  |  2 The mechanism of action of minoxidil is unknown, but does not involve androgen pathways. 8) Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone. The children subsequently developed a condition called “werewolf syndrome” in which large parts of their bodies become covered in hair. alopecia with oral minoxidil either alone or in combination with antiandrogens on 18 August 2011. But i did not lose much if any ground switching from Oral spironolactone to topical RU after a few years because they have similar modes of action. Low-dose oral minoxidil (0.25mg daily) has been successfully used in combination with spironolactone in the treatment of female pattern hair loss (FPHL) 1.Oral minoxidil (5mg daily) has been shown to be efficacious in male pattern hair loss (MPHL) 2,3.The objective of our study was to evaluate the efficacy and safety of low-dose sublingual minoxidil (0.45mg daily) in MPHL and FPHL. 2020 Dec;10(6):1345-1357. doi: 10.1007/s13555-020-00448-x. There was a slight reduction in mean blood pressure of 4.52 mmHg systolic and 6.48 mgHg diastolic. © 2017 The International Society of Dermatology. Introduction. Application of minoxidil does have it's own unique set of challenges. Oral Minoxidil . Suchonwanit P, Iamsumang W, Rojhirunsakool S. Am J Clin Dermatol. Website Disclaimer, Scarring Alopecia - Frequently Asked Questions, Alopecia areata - Frequently Asked Questions, Our International Hair Loss Course for Physicians, APPOINTMENT TODAY? Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone.Int. Female Pattern Hair Loss (FPHL), also known as female hair thinning or female androgenetic alopecia is a common type of hair loss that affects about one-third of women. Our Laboratory also produces a prescription range of hair lotions which can include Minoxidil, Retinoic acid, finasteride, progesterone and spironolactone. This study is interesting because of the safety and limited side effects that were observed. 2012 May;6(2):130-6. doi: 10.2174/187221312800166859. Australas J Dermatol. eCollection 2019. Has anyone had any experience with this? The mean age was 48.44 years and the mean duration of diagnosis was 6.5 years. Only 2 % of patients dropped out of the study. Efficacy of Topical Combination of 0.25% Finasteride and 3% Minoxidil Versus 3% Minoxidil Solution in Female Pattern Hair Loss: A Randomized, Double-Blind, Controlled Study. The content of this website is intended to provide accurate, up-to-date and scientifically-based information on all aspects of hair loss. Pindado-Ortega C, Saceda-Corralo D, Fernández-Nieto D, Jiménez-Cauhé J, Ortega-Quijano D, Moreno-Arrones ÓM, Vañó-Galván S. Skin Appendage Disord. Treatment of female pattern hair loss with a combination of spironolactone and minoxidil. Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone. Oral minoxidil has been around for many decades and was originally used as a blood pressure medication. The subject was initially treated with a 200 mg oral dose of spironolactone daily. The dose of minoxidil prescribed was 0.25 mg and the dose of spironolactone used was 25 mg. 100 women were included in this study. J. Dermatol. Compare Minoxidil Topical vs Spironolactone head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Sinclair RD, International Journal of Dermatol, 2018, Jan;57 (1): 104-108. In another study by Dr. Sinclair (of chronic telogen effluvium) which also involved study of oral minoxidil, there were no drop outs. Once daily capsules containing minoxidil 0.25 mg and spironolactone 25 mg appear to be safe and effective in the treatment of FPHL. Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment. The use of oral minoxidil is FDA approved for high blood pressure. Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone. COVID-19 is an emerging, rapidly evolving situation. Limitations: Background: Minoxidil and spironolactone are oral antihypertensives known to stimulate hair growth. Recently there has been increased interest worldwide in understand the potential benefits of using low dose oral minoxidil to treat hair loss. Any affects on your face/skin texture.. or affects on scalp? Minoxidil can be used in adults and children (although its effectiveness and safety in children have been understudied). eCollection 2020 Jul-Aug. Rodrigues-Barata R, Moreno-Arrones OM, Saceda-Corralo D, Jiménez-Cauhé J, Ortega-Quijano D, Fernández-Nieto D, Jaén-Olasolo P, Vaño-Galvan S. Skin Appendage Disord. Epub 2017 Dec 12. I think minoxidil is a very specialist product and if you were to stop oral minoxidil some hairs would be lost unless you replaced with something similar i.e topical minoxidil. Only 2 of the 100 patients overall discontinued treatment and these were patients with hives (urticaria). Oral Minoxidil and Spiro. See Article “The Top 10 Things You need to Know About Oral Minoxidil”. [The treatment of female pattern hair loss].  |  2018; JIMENEZ J., SACEDA CORRALO D. RODRIGUEZ BARATA R., VAÑÓ-GALVAN S. Effectiveness and safety of low-dose oral minoxidil in male androgenetic alopecia.JAAD , 2019 , May. Epub 2020 Feb 21. Int J Dermatol. Rather than using the 10-40 mg doses that were once used to treat blood pressure, low dose oral minoxidil for hair loss involves doses ranging from 0.25 mg to 2.5 mg. Rod Sinclair from Australia set out to study the potential benefits of using oral minoxidil and oral spironolactone together. Other less common side effects are typically headaches, ankle swelling, hives. More studies of oral minoxidil are needed but studied to date are promising. The most common side effect in practice is increased hair on the upper lip in 25- 35 % of women. 1) Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone. Side effects were seen in eight women but were generally mild. And alternative options – such as scalp massage and microneedling – also exist. Prospective, uncontrolled, open-label observational study. 8 % of patients in the study have side effects but they were deemed mild. Messenger AG 1, Rundegren J., Br J Dermatol, 2004 Feb; 150 (2): 186-94 Dermatol Ther . 1. share. HHS It is known to increase hair growth on the body as a side effects. Once a day over 12 months, each woman took a capsule that contained 25 milligrams (mg) of spironolactone and 0.25 mg of oral minoxidil. Mean hair shedding score at baseline was 4.82. 2019 Feb;20(1):147-153. doi: 10.1007/s40257-018-0387-0. Some of the benefits of using a combination of low dose oral Minoxidil and Spironolactone include: Improvements in the parietal scalp, and Improvements in temporal hair growth Mean reduction in hair loss severity score was 0.85 at 6 months and 1.3 at 12 months. 2012. It should not be considered a substitute for professional medical advice. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Objective: Topical Minoxidil remains the only formally FDA and Health Canada approved treatment for FPHL. Note Spironolactone and Minoxidil should never be combined in the same lotion due to instability issues. Objective To report on a case series of women with pattern hair loss (PHL) treated with once daily minoxidil 0.25 mg and spironolactone 25 mg. HOME        RESEARCH     BIO - DR. DONOVAN     DAILY BLOG     CONTACT US, 4370 Lorimer Road, Suite 334B Whistler, BC, Canada (604) 283-1887. Minoxidil (Rogaine) and spironolactone are used widely by women with hair loss to slow shedding and induce growth. The diagnosis of FPHL is associated with underlying hypertension in women aged £35 years and coronary artery disease in women aged £50 years.7 One study found that patterned hair loss was an in… Learn about drug interactions between minoxidil oral and spironolactone oral and use the RxList drug interaction checker to check drug combinations. All causes of hyperandrogenism, such as ovarian or adrenal tumours, polycystic ovarian syndrome and adrenal hyperplasia, can induce rapid hair loss in women. It was at this point in the study that a twice daily dose of minoxidil 5% solution was prescribed, and further hair regrowth was documented. Mean hair loss severity at baseline was Sinclair 2.79 (range 2-5). 2018 Jan;57(1):104-109. doi: 10.1111/ijd.13838. eCollection 2017. Clipboard, Search History, and several other advanced features are temporarily unavailable. Luckily, the body hair will disappear a few months after the children stop taking oral Minoxidil. Suchonwanit P, Thammarucha S, Leerunyakul K. Drug Des Devel Ther. Most women affected by the condition start with slightly increased hair shedding. Over time, the patient notices decreased hair density and a more see through appearance to the scalp. Hi anyone taking 0.625 mg Oral Minoxidil along with 25mg spironolactone? How long before you saw results and have you had any side effects. But when it comes right down to it, the fact of the matter is you need to treat the underlying cause of your condition if you want to stop hair loss and perhaps even regrow your hair. Other options including oral anti-androgens, laser, PRP and hair transplantation (for some women). Treatment of chronic telogen effluvium with oral minoxidil: A retrospective study. Case series of oral minoxidil for androgenetic and traction alopecia: Tolerability & the five C’s of oral therapy. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. In fact, it was Dr Sinclair who showed this many years ago as well. What sort of … Many patients give up after a period of time. All photos and information in this website is copyrighted unless otherwise stated. Indian Dermatol Online J. Minoxidil and spironolactone are oral antihypertensives known to stimulate hair growth. Please enable it to take advantage of the complete set of features! Six of these women continued treatment, and two women who developed urticaria discontinued treatment. Rodney D. Sinclair, Female pattern hair loss: a pilot study investigating combination therapy with low‐dose oral minoxidil and spironolactone, International Journal of Dermatology, 10.1111/ijd.13838, 57, 1, (104-109), (2017). Low-Dose Oral Minoxidil for Female Pattern Hair Loss: A Unicenter Descriptive Study of 148 Women. Epub 2020 Sep 24. The dose of minoxidil prescribed was 0.25 mg and the dose of spironolactone used was 25 mg. 100 women were included in this study. She had documented hair regrowth at the 12-month mark, though, hair growth did eventually plateau by the 24-month mark. 2019 Aug 9;13:2777-2786. doi: 10.2147/DDDT.S214907. When taken separately, each of … Placebo-controlled studies to investigate this further are warranted. Sinclair RD. NIH Women newly diagnosed with a Sinclair stage 2-5 PHL were scored for hair shedding and hair density before and after 12 months of treatment with oral minoxidil 0.25 mg and spironolactone 25 mg. HealthDay News — Once-daily capsules containing a combination of minoxidil and spironolactone appear to be safe and effective for the treatment of … Abstract Background Minoxidil and spironolactone are oral antihypertensives known to stimulate hair growth. 2020 Sep;6(5):283-286. doi: 10.1159/000509063. A total of 100 women were included in this observational pilot study. If you are going to use or prescribe oral minoxidil, you need to know a thing or two (or three) about it - … Its use in hair loss is entirely off label. 2020 Jul 13;11(4):493-501. doi: 10.4103/idoj.IDOJ_334_19. No patients developed hyperkalemia or any other blood test abnormality. Mean age was 48.44 years (range 18-80). - BEGIN YOUR TELEMEDICINE CONSULT NOW, PLANNING YOUR FIRST VISIT WITH DR. DONOVAN, FREQUENTLY ASKED QUESTIONS ABOUT THE FIRST VISIT, FREQUENTLY ASKED QUESTIONS ABOUT SUBSEQUENT APPOINTMENTS, INFORMATION ON FOLLOW UP APPOINTMENT FREQUENCY, SEND US DOCUMENTS AND PHOTOS (SECURE UPLOAD LINK), Referral Information & Form for Physicians, Dr. Donovan's Hair Loss Articles (2011-2020), Combining Oral Minoxidil and Oral Spironolactone for FPHL. Oral minoxidil is not FDA approved for hair loss. The ease of taking oral minoxidil vs topical minoxidil does make it a important option for further study. 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